COPD: An Essential Guide to Unraveling Causes, Implications, and Management

▫️Written by John Keller

✅ Reviewed by Dr. Jenny Hynes on AUGUST 11, 2023


  1. What Is COPD?

  2. COPD Causes and Risk Factors

  3. COPD Symptoms and Diagnosis

  4. COPD Treatment Options

  5. The Role of Physiotherapy in COPD Management

  6. COPD Rehabilitation and Self-Management

  7. COPD Prevention and Lifestyle Tips

  8. Conclusion

Chronic Obstructive Pulmonary Disease (COPD), a debilitating respiratory condition marked by persistent breathlessness and decreased lung function, presents a profound impact on the daily lives of those affected. In Australia, COPD is not only a significant public health concern but also a pervasive socio-economic burden. As per the Australian Burden of Disease Study (2019), COPD ranked seventh among the leading causes of total burden of disease, accounting for 2.5% of the total burden and a staggering 4.3% among those aged 65 and over. By 2023, it was estimated that 1 in 13 Australians aged 40 years or older will be living with COPD (Toelle et al., 2023).

The magnitude of this problem underscores the importance of early diagnosis and appropriate treatment. For many, COPD can go undiagnosed or undertreated until the later stages of the disease, exacerbating symptoms and decreasing quality of life. This makes timely intervention and optimal management strategies imperative to mitigating disease progression and improving patient outcomes. 

Among various treatment modalities, physiotherapy has emerged as a crucial aspect of COPD management. Research has consistently illustrated its potential role in enhancing respiratory function, improving exercise capacity, reducing breathlessness, and enhancing the overall quality of life (Osadnik et al., 2022). 

Despite these benefits, the role of physiotherapy in COPD management is often overlooked. This potentially leaves a vast scope for improving COPD outcomes, suggesting a need for greater recognition and incorporation of physiotherapy within integrated COPD care models. 

In a bid to confront this health crisis, we delve into understanding the intricacies of COPD, the significance of early diagnosis, appropriate treatment measures, and the invaluable role of physiotherapy in its management. In this exploration, we lean on the most current, high-quality research articles to ensure our understanding is both comprehensive and up-to-date, enabling us to contribute meaningfully to improving COPD care in Australia and beyond.

What Is COPD?

Chronic Obstructive Pulmonary Disease (COPD) is a complex, progressive lung disease characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities, typically caused by significant exposure to noxious particles or gases (Global Initiative for Chronic Obstructive Lung Disease, 2020). 

The underlying pathological processes in COPD involve chronic inflammation in the airways, lung parenchyma, and pulmonary vasculature. This chronic inflammation leads to a number of structural changes, known as 'remodeling', causing progressive and irreversible airflow limitation. Such changes include bronchial wall thickening, destruction of the elastic alveolar walls (emphysema), and narrowing and obliteration of small airways (Rabe et al., 2007).

Moreover, COPD is characterized by episodes of acute exacerbation, where symptoms suddenly get worse and stay worse, leading to additional damage to the lungs. These exacerbations are often triggered by respiratory infections or exposure to environmental pollutants.

Differentiating COPD from other respiratory conditions such as asthma is paramount for targeted treatment. COPD and asthma, for example, both involve airflow obstruction and inflammation, yet they differ in their underlying pathophysiology, response to therapy, and disease progression. Asthma is typically characterized by episodic symptoms and reversible airflow limitation, in contrast to the persistent and progressive nature of COPD (Postma & Rabe, 2015).

Understanding COPD's definition, characteristics, and differentiation from other respiratory diseases is fundamental in effectively managing this condition, optimizing patient outcomes, and enhancing their quality of life.

 
 

COPD Causes and Risk Factors

The development and progression of Chronic Obstructive Pulmonary Disease (COPD) can be attributed to a multitude of risk factors. The most prevalent of these is smoking, with research indicating that up to 50% of long-term smokers will develop COPD (Tashkin & Murray, 2009). Exposure to tobacco smoke triggers an inflammatory response in the lungs, resulting in structural changes and progressive airflow limitation.

Second-hand smoke is also a significant risk factor. Non-smokers living with individuals who smoke are exposed to many of the same harmful chemicals. Children exposed to second-hand smoke have an increased risk of developing COPD in adulthood (Jaakkola & Jaakkola, 2002).

Exposure to environmental pollutants plays a crucial role in the development of COPD. This includes occupational exposure to dust, chemicals (such as cadmium and silica), and fumes from burning biomass fuels, commonly used for cooking and heating in poorly ventilated homes (Sood, 2012). 

Genetic factors, while not as common, can also contribute to COPD. The most well-known genetic risk factor is alpha-1 antitrypsin deficiency, a condition that can lead to lung disease in adults and liver disease in adults and children (Silverman & Sandhaus, 2009).

Additionally, frequent respiratory infections, particularly during childhood, can lead to long-term damage to the lungs and increase the risk of developing COPD (Qiu et al., 2003).

Identifying and avoiding exposure to these COPD triggers is essential in preventing or slowing the disease's progression. This includes:

1.Smoking Cessation

This is the most effective way to prevent the onset of COPD or to slow its progression if already diagnosed. Quitting smoking can be challenging, but various resources and aids are available, including nicotine replacement therapies, medications, counselling services, and support groups. Creating a detailed plan and involving health care providers in the process can significantly improve the chances of successful cessation (Kruger, Shaw, Kahende, & Frank, 2012).

2. Avoiding Second-Hand Smoke

Minimize exposure to second-hand smoke by avoiding areas where people are smoking. For non-smokers living with smokers, encourage smoking cessation, or at least ensure the smoking is done outside or in a well-ventilated area. Implementing smoke-free policies in homes and cars can also significantly reduce exposure (Hyland et al., 2009).

3. Occupational Safety and Environmental Hazards

For those working in industries with exposure to dust, chemicals, or fumes, proper protective equipment such as masks or respirators is vital. Regular health check-ups and monitoring of lung function can help detect any early signs of lung disease. Limit exposure to biomass smoke by improving ventilation, using cleaner fuels, and efficient stoves if possible (Sood, 2012).

4. Managing Respiratory Infections

Frequent hand-washing, staying up-to-date with vaccinations (like the annual flu shot and pneumococcal vaccine), and maintaining good overall health can help prevent respiratory infections that may worsen COPD. 

5. Genetic Testing

For those with a family history of COPD, particularly if they develop COPD despite having never smoked, a genetic test for alpha-1 antitrypsin deficiency could be beneficial (DeMeo & Silverman, 2004). Early detection can lead to more effective management strategies and help prevent further lung damage.

By understanding and actively mitigating these risk factors, individuals can significantly reduce their risk of developing COPD or prevent further progression of the disease.

COPD Symptoms and Diagnosis

Chronic Obstructive Pulmonary Disease (COPD) is characterized by a variety of respiratory symptoms. Typical manifestations of the disease include shortness of breath (dyspnea), particularly during physical activity, a chronic and often productive cough, wheezing, and chest tightness (Vestbo et al., 2013). Frequent respiratory infections and fatigue can also occur. In the disease's advanced stages, symptoms such as weight loss and swelling in the ankles, feet, or legs may be present due to complications like heart failure.

Diagnosing COPD involves a comprehensive approach that includes patient history, physical examination, and various diagnostic tests. A detailed medical history is crucial in identifying risk factors, such as smoking or occupational exposures. Physical examination alone is not sufficient for diagnosis, but it can reveal signs of COPD like wheezing or reduced breath sounds (Qaseem et al., 2011).

Lung function tests, specifically spirometry, are critical in the diagnosis of COPD. Spirometry measures how much air a person can exhale and how quickly, quantifying the degree of airflow obstruction. The key spirometric finding in COPD is a reduced ratio of the volume of air forcefully exhaled in the first second to the total volume of air forcefully exhaled (FEV1/FVC ratio) after the administration of a bronchodilator (Global Initiative for Chronic Obstructive Lung Disease, 2020).

Additional diagnostic tools like chest imaging, including chest X-ray or computed tomography (CT), and blood tests to rule out other conditions can provide further information. A CT scan can provide detailed images of the lungs and help detect emphysema, a common feature of COPD (Qaseem et al., 2011).

Early diagnosis and intervention of COPD are paramount. The progression of the disease can be slowed, and the patient's quality of life can be improved with the correct management strategies. These can include smoking cessation, pharmacotherapy, pulmonary rehabilitation, and, in some cases, oxygen therapy (Global Initiative for Chronic Obstructive Lung Disease, 2020).

 
 

COPD Treatment Options

Treatment for Chronic Obstructive Pulmonary Disease (COPD) is multifaceted, and the primary goals are to manage symptoms, improve lung function, enhance exercise tolerance, and prevent exacerbations or complications (Global Initiative for Chronic Obstructive Lung Disease, 2020). 

1. Medications

Pharmacological management of COPD involves several classes of medications. Bronchodilators, including beta-agonists and anticholinergics, help relax the muscles around the airways, improving airflow and reducing symptoms like shortness of breath and exercise limitations. Inhaled corticosteroids are often used for patients with frequent exacerbations or those with an asthmatic component (Nici et al., 2020).

2. Oxygen Therapy

For patients with severe COPD who have low levels of oxygen in their blood, supplemental oxygen can alleviate symptoms, improve quality of life, and increase survival (Hardinge et al., 2015).

3. Pulmonary Rehabilitation

This comprehensive program includes exercise training, education about COPD, nutrition advice, and counseling. It aims to improve physical and psychological conditions and promote long-term adherence to health-enhancing behaviors (McCarthy et al., 2015).

4. Lifestyle Modifications

Beyond medications and formal programs, changes to everyday life can also help manage COPD. These include smoking cessation, avoiding COPD triggers, maintaining a healthy diet, and staying physically active as tolerated.

Given the chronic and heterogeneous nature of COPD, an individualized treatment plan is essential and should be tailored to the patient's specific needs and disease severity. The plan should be reviewed and updated regularly, considering the patient's symptom burden, exacerbation risk, and response to treatment (Global Initiative for Chronic Obstructive Lung Disease, 2020).

The Role of Physiotherapy in COPD Management

Physiotherapy plays a crucial role in the management of Chronic Obstructive Pulmonary Disease (COPD), aiding in the optimization of physical performance, respiratory function, and overall well-being (Spruit et al., 2013). 

Exercise and Pulmonary Rehabilitation

Pulmonary rehabilitation programs, led by the physiotherapists here at Keilor Road Physiotherapy, are a key part of COPD management. These programs typically consist of exercise training, education, and behavioural change, aimed at improving physical and psychological conditions. It has been consistently shown that such programs can significantly improve exercise capacity, reduce perceived breathlessness, enhance muscle strength and endurance, and boost overall health status in individuals with COPD (McCarthy et al., 2015).

Breathing Retraining and Airway Clearance Techniques

Physiotherapists can teach techniques to help individuals with COPD control their breathing and clear their airways more effectively. These can include pursed-lip breathing, diaphragmatic breathing, and use of devices like flutter valves to aid in mucus clearance (Holland et al., 2012).

Energy Conservation Strategies

These strategies can help individuals with COPD to perform their daily activities more efficiently, reducing breathlessness and fatigue. This might involve teaching techniques to perform tasks in a more energy-efficient manner, or advising on pacing and prioritization of tasks (Slinde et al., 2011).

Keilor Road Physiotherapy provides comprehensive physiotherapy services that can be beneficial for individuals with COPD. These can include personalized exercise programs, education about the disease and self-management strategies, and interventions such as manual therapy techniques. Ultimately, physiotherapy is an essential component of a comprehensive COPD management plan, helping individuals to manage their symptoms, improve their function, and enhance their quality of life.

COPD Rehabilitation and Self-Management

Living with Chronic Obstructive Pulmonary Disease (COPD) requires ongoing management and engagement with various rehabilitation strategies. Central to this is the self-management of the condition, involving adherence to prescribed medications, engagement in regular physical activity, maintaining proper nutrition, and stress management (Effing et al., 2016). 

Physiotherapy and Rehabilitation Exercises

Physiotherapists, such as those at Keilor Road Physiotherapy, have an important role in guiding individuals with COPD through targeted exercises as part of pulmonary rehabilitation. These exercises aim to enhance cardiovascular fitness, improve muscle strength and flexibility, and enhance overall functional capacity. These can include activities such as walking, cycling, strength training, and flexibility exercises, all adapted to an individual's abilities and health status (Spruit et al., 2013).

Self-Management and Physiotherapy

Physiotherapists also educate individuals about their condition, encourage adherence to their medication regime, and promote beneficial lifestyle changes. In addition, they provide strategies to manage breathlessness, conserve energy, clear airways, and manage stress and anxiety related to COPD (Effing et al., 2016). 

Keilor Road Physiotherapy offers tailored COPD programs that include moderate-intensity aerobic exercises like walking or cycling, strength training for the upper and lower body, and Pilates and flexibility exercises to promote mobility and balance. These are designed not just to improve physical function but also to help manage symptoms and enhance overall quality of life. An example might look like:

1. Cardiovascular Fitness: Moderate-intensity aerobic activities such as walking or cycling for 20-30 minutes a day, 3-5 times a week.

2. Strength Training: Exercises targeting both the upper and lower body, such as Keilor Road Physiotherapy Studio or Strength and Conditioning classes, performed 2-3 times a week.

3. Flexibility Exercises: Daily stretches to improve mobility and reduce muscle stiffness included for the thoracic spine, lumbar spine, hips and pelvis. 

4. Pilates: Pilates exercises focused on controlled breathing and core strengthening, performed under the guidance of a qualified instructor, for 2-3 sessions a week.

5. Education and Self-Management Skills: Regular sessions to reinforce understanding of the condition, medication usage, and techniques for symptom management.

Working with an expert Keilor Road Physiotherapy physiotherapist to develop an appropriate plan can ensure that the exercise regime is safe, effective, and tailored to the individual's specific needs and capabilities. 

COPD Prevention and Lifestyle Tips

Prevention and lifestyle modifications play an integral role in managing COPD and can also play a role in preventing its onset, particularly in individuals who are at high risk. Prevention tips include:

1. Avoid Smoking and Exposure to Pollutants

Smoking is the most significant risk factor for COPD (Vogelmeier et al., 2017). Quitting smoking and avoiding secondhand smoke are crucial for preventing COPD. It is also important to avoid exposure to indoor and outdoor pollutants, such as dust, chemical fumes, and air pollution.

2. Maintain Good Indoor Air Quality

Using air purifiers, maintaining cleanliness, and ensuring proper ventilation can help improve indoor air quality (Hulin et al., 2012). They work by removing particulate matter, which includes dust, pet dander, smoke particles, and certain types of pollen, from the air. 

A study published in the American Journal of Respiratory and Critical Care Medicine found that air purifiers significantly reduced particulate matter in homes, and participants with COPD experienced fewer respiratory symptoms and flare-ups (Chen et al., 2015). However, the study also suggests that the effectiveness of air purifiers in improving COPD outcomes may depend on the types and levels of pollutants in a person's home environment and the amount of time spent at home.

In a systematic review by Zhang and colleagues (2011), they found that most studies reported beneficial effects of using air purifiers on lung function in COPD patients. 

3. Proper Hand Hygiene and Vaccinations

Regular hand washing can prevent respiratory infections, which may exacerbate COPD and accelerate lung function decline. Staying up-to-date with vaccinations, such as the annual flu shot and the pneumonia vaccine, can also help prevent infections that could potentially worsen COPD (MacIntyre et al., 2008).

Hand hygiene is one of the simplest yet most effective methods of preventing the spread of many types of infection and illness. Hands can act as a bridge to transfer bacteria and viruses from contaminated surfaces to the body. Therefore, regular and proper handwashing, especially before eating or touching the face, and after being in public places, can help reduce the risk of respiratory infections.

According to a study published in the American Journal of Respiratory and Critical Care Medicine, COPD patients who had a recent respiratory infection had an almost two-fold increased risk of having a severe COPD exacerbation (Hurst et al., 2010). This underscores the importance of avoiding respiratory infections in COPD management.

Getting vaccinated is another important measure to prevent respiratory infections. The flu (influenza) and pneumonia vaccines are particularly recommended for individuals with COPD, as these respiratory infections can be severe in these individuals and can lead to COPD exacerbations (MacIntyre et al., 2008).

Lifestyle Tips

  1. Regular Check-ups and Early Detection: Regular check-ups with a GP allow for early detection of symptoms and timely management of COPD. Adherence to recommended treatment plans, such as those from Keilor Road Physiotherapy, can help to manage symptoms and slow disease progression (Jenkins et al., 2017).

  2. Healthy Lifestyle: A balanced diet rich in fruits, vegetables, lean proteins, and whole grains can support overall health. Regular exercise, as recommended by a healthcare professional, can help improve lung capacity and physical endurance. 

  3. Stress Management: Stress management is an integral part of chronic disease management, including COPD. Chronic stress can exacerbate symptoms, affect overall well-being, and potentially contribute to more frequent exacerbations.

Living with COPD often presents numerous challenges that can be stressful, such as dealing with symptoms, managing medications, adjusting lifestyle habits, and coping with potential changes in physical ability and quality of life. This can lead to elevated stress levels, anxiety, and even depression.

A study in the International Journal of Chronic Obstructive Pulmonary Disease indicated that psychological stress can adversely affect COPD outcomes, including exacerbation rates, hospital readmissions, and overall quality of life (Willgoss and Yohannes, 2013). This underlines the importance of stress management in the overall treatment plan for COPD.

Stress management techniques for individuals with COPD may include:

  1. Breathing Exercises: Controlled breathing techniques, such as pursed-lip breathing and diaphragmatic breathing, can help manage stress, improve oxygenation, and reduce breathlessness (O'Donnell et al., 2008).

  2. Mindfulness and Relaxation Exercises: Techniques such as meditation, progressive muscle relaxation, and yoga can help reduce stress, improve mood, and enhance overall wellbeing (Farver-Vestergaard et al., 2015).

  3. Physical Activity: Regular exercise can promote feelings of well-being, improve physical capacity, and help reduce stress levels (Cindy Ng, L. W., Mackney, J., Jenkins, S., & Hill, K., 2012).

  4. Psychotherapy: Cognitive-behavioral therapy (CBT) and other psychotherapy approaches can help individuals cope with stress, address anxieties related to their illness, and improve coping mechanisms (Coventry, P. A., 2009).

  5. Social Support: Connection with others, such as through support groups, can provide emotional assistance and shared coping strategies, reducing feelings of isolation and stress (Barrera, M., Toobert, D. J., & Strycker, L. A., 2012).

Keilor Road Physiotherapy can provide further education on these lifestyle modifications, and help create personalized management plans that incorporate these prevention strategies.

Conclusion

Chronic Obstructive Pulmonary Disease (COPD) presents a significant burden to the health and well-being of a large segment of the population, with approximately 1 in 13 Australians aged 40 and over living with this condition (Toelle et al., 2013). Understanding COPD, its causes, symptoms, diagnosis, and treatment options is paramount to effective disease management and mitigation of its impacts on daily life.

COPD, characterised by chronic inflammation, progressive airflow limitation, and damage to the lungs, is most commonly caused by smoking, exposure to environmental pollutants, genetic factors, and respiratory infections. Awareness and avoidance of these risk factors, coupled with a focus on early diagnosis and appropriate treatment, can significantly enhance disease prognosis and reduce the severity of symptoms. 

An array of treatment options, including medications, oxygen therapy, pulmonary rehabilitation, and lifestyle modifications, cater to the individual needs of patients, aiming to alleviate symptoms, improve lung function, enhance exercise tolerance, and prevent exacerbations. Notably, physiotherapy interventions have shown substantial promise in managing COPD, offering improvements in exercise capacity, reduction in breathlessness, enhanced muscle strength and endurance, and overall wellbeing. Specifically, tailored programs like those provided by Keilor Road Physiotherapy, which integrate a range of exercises and rehabilitation techniques, including Pilates, can be extremely beneficial. 

Crucial to managing COPD is the patient's proactive role in self-management, including adherence to prescribed medications, regular physical activity, proper nutrition, and stress management. The use of air purifiers, diligent hand hygiene, and staying up-to-date with vaccinations are further proactive strategies to minimize COPD exacerbations and improve the quality of life. 

While COPD is a pervasive condition with potentially significant impacts on daily life, its effects can be mitigated with the right knowledge, treatment, and lifestyle adjustments. With the integration of medical care, physiotherapy, and patient-driven lifestyle modifications, individuals living with COPD can lead a fulfilling life, maintaining their functional independence and improving their quality of life.

 

References

  1. Australian Institute of Health and Welfare (2019). Australian Burden of Disease Study: Impact and causes of illness and death in Australia 2015. Australian Burden of Disease series no. 19. Cat. no. BOD 22. Canberra: AIHW.

  2. Barrera, M., Toobert, D. J., & Strycker, L. A. (2012). Social support resources of Latinos with diabetes. Chronic illness, 31(1), 51-54.

  3. Chen, R., Zhao, A., Chen, H., Zhao, Z., Cai, J., Wang, C., Yang, C., Li, H., Xu, X., Ha, S., Li, T., & Kan, H. (2015). Cardiopulmonary benefits of reducing indoor particles of outdoor origin: a randomized, double-blind crossover trial of air purifiers. Journal of the American College of Cardiology, 65(21), 2279–2287. https://doi.org/10.1016/j.jacc.2015.03.553

  4. Cindy Ng, L. W., Mackney, J., Jenkins, S., & Hill, K. (2012). Does exercise training change physical activity in people with COPD? A systematic review and meta-analysis. Chronic Respiratory Disease, 9(1), 17-26. https://doi.org/10.1177/1479972311430335

  5. Coventry, P. A. (2009). Does pulmonary rehabilitation reduce anxiety and depression in chronic obstructive pulmonary disease?. Current Opinion in Pulmonary Medicine, 15(2), 143-149. https://doi.org/10.1097/MCP.0b013e328325a4c3

  6. DeMeo, D. L., & Silverman, E. K. (2004). Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha (1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk. Thorax, 59(3), 259-264. https://doi.org/10.1136/thorax.2003.006502

  7. Effing, T. W., Vercoulen, J. H., Bourbeau, J., Trappenburg, J., Lenferink, A., Cafarella, P., ... & van der Palen, J. (2016). Definition of a COPD self-management intervention: International Expert Group consensus. European Respiratory Journal, 48(1), 46-54. https://doi.org/10.1183/13993003.00025-2016

  8. Farver-Vestergaard, I., Jacobsen, D., & Zachariae, R. (2015). Efficacy of psychosocial interventions on psychological and physical health outcomes in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Psychotherapy and psychosomatics, 84(1), 37-50. https://doi.org/10.1159/000363165

  9. Global Initiative for Chronic Obstructive Lung Disease. (2020). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (2020 report). https://goldcopd.org/wp-content/uploads/2019/12/GOLD-2020-FINAL-ver1.2-03Dec19_WMV.pdf

  10. Hardinge, M., Annandale, J., Bourne, S., Cooper, B., Evans, A., Freeman, D., ... & Wilkinson, T. (2015). British Thoracic Society guidelines for home oxygen use in adults. Thorax, 70(Suppl 1), i1-i43. https://doi.org/10.1136/thoraxjnl-2015-206865

  11. Holland, A. E., Hill, C. J., Jones, A. Y., & McDonald, C. F. (2012). Breathing exercises for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews, (10). https://doi.org/10.1002/14651858.CD008250.pub2

  12. Hulin, M., Simoni, M., Viegi, G., & Annesi-Maesano, I. (2012). Respiratory health and indoor air pollutants based on quantitative exposure assessments. The European respiratory journal, 40(4), 1033–1045.

  13. Hurst, J. R., Vestbo, J., Anzueto, A., Locantore, N., Müllerova, H., Tal-Singer, R., ... & Wedzicha, J. A. (2010). Susceptibility to exacerbation in chronic obstructive pulmonary disease. New England Journal of Medicine, 363(12), 1128-1138. https://doi.org/10.1056/NEJMoa0909883

  14. Hyland, A., Barnoya, J., & Corral, J. E. (2012). Smoke-free air policies: past, present and future. Tobacco Control, 21(2), 154-161. 

  15. Jaakkola, M. S., & Jaakkola, J. J. (2002). Effects of environmental tobacco smoke on the respiratory health of adults. Scandinavian Journal of Work, Environment & Health, 81-96. https://www.jstor.org/stable/40967562

  16. Jenkins, C. R., Chapman, K. R., Donohue, J. F., Roche, N., Tsiligianni, I., & Han, M. K. (2017). Improving the Management of COPD in Women. Chest, 151(3), 686–696. https://doi.org/10.1016/j.chest.2016.10.031

  17. Kruger, J., Shaw, L., Kahende, J., & Frank, E. (2012). Health care providers' advice to quit smoking, National Health Interview Survey, 2000, 2005, and 2010. Preventing chronic disease, 9, E130. https://doi.org/10.5888/pcd9.110340

  18. MacIntyre, N. R., & Huang, Y. C. (2008). Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society, 5(4), 530-535. https://doi.org/10.1513/pats.200708-126ET

  19. McCarthy, B., Casey, D., Devane, D., Murphy, K., Murphy, E., & Lacasse, Y. (2015). Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews, (2). https://doi.org/10.1002/14651858.CD003793.pub3

  20. Nici, L., Mammen, M. J., Charbek, E., Alexander, P. E., Au, D. H., Boyd, C. M., ... & Rochester, C. L. (2020). Pharmacologic management of chronic obstructive pulmonary disease. An official American Thoracic Society clinical practice guideline. American journal of respiratory and critical care medicine, 201(9), e56-e69. https://doi.org/10.1164/rccm.202003-0625ST

  21. O'Donnell, D. E., Hernandez, P., Kaplan, A., Aaron, S., Bourbeau, J., Marciniuk, D., ... & Voduc, N. (2008). Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease—2008 update—highlights for primary care. Canadian respiratory journal, 19(1), 25-36. https://doi.org/10.1155/2008/594561

  22. Osadnik, C. R., McDonald, C. F., Jones, A. P., & Holland, A. E. (2012). Airway clearance techniques for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews, 2012(3), CD008328. https://doi.org/10.1002/14651858.CD008328.pub2.

  23. Postma, D. S., & Rabe, K. F. (2015). The Asthma–COPD Overlap Syndrome. New England Journal of Medicine, 373(13), 1241-1249. https://doi.org/10.1056/NEJMra1411863

  24. Qaseem, A., Wilt, T. J., Weinberger, S. E., Hanania, N. A., Criner, G., van der Molen, T., ... & Schünemann, H. (2011). Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. Annals of internal medicine, 155(3), 179-191. https://doi.org/10.7326/0003-4819-155-3-201108020-00008

  25. Qiu, Y., Zhu, J., Bandi, V., Atmar, R. L., Hattotuwa, K., Guntupalli, K. K., & Jeffery, P. K. (2003). Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine, 168(8), 968–975. https://doi.org/10.1164/rccm.200208-794OC

  26. Rabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., ... & Jones, P. W. (2007). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. American journal of respiratory and critical care medicine, 176(6), 532-555. https://doi.org/10.1164/rccm.200703-456SO

  27. Silverman, E. K., & Sandhaus, R. A. (2009). Alpha1-Antitrypsin deficiency. New England Journal of Medicine, 360(26), 2749-2757. https://doi.org/10.1056/NEJMcp0900449

  28. Slinde, F., Grönberg, A. M., Svantesson, U., Hulthén, L., & Larsson, S. (2011). Energy expenditure in chronic obstructive pulmonary disease-evaluation of simple measures. European journal of clinical nutrition, 65(12), 1309–1313. https://doi.org/10.1038/ejcn.2011.117

  29. Sood, A. (2012). Indoor fuel exposure and the lung in both developing and developed countries: an update. Clinics in Chest Medicine, 33(4), 649-665. https://doi.org/10.1016/j.ccm.2012.06.003

  30. Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., ... & Anzueto, A. (2013). An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. American journal of respiratory and critical care medicine, 188(8), e13-e64. https://doi.org/10.1164/rccm.201309-1634ST

  31. Tashkin, D. P., & Murray, R. P. (2009). Smoking cessation in chronic obstructive pulmonary disease. Respiratory medicine, 103(7), 963-974. https://doi.org/10.1016/j.rmed.2009.01.018

  32. Toelle, B. G., Xuan, W., Bird, T. E., Abramson, M. J., Atkinson, D. N., Burton, D. L.,Rodriguez-Roisin, R. (2000). Toward a consensus definition for COPD exacerbations. Chest, 117(5_suppl_2), 398S-401S. https://doi.org/10.1378/chest.117.5_suppl_2.398S

  33. Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., ... & Fabbri, L. M. (2013). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. American journal of respiratory and critical care medicine, 187(4), 347-365. https://doi.org/10.1164/rccm.201204-0596PP

  34. Vogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., ... & Frith, P. (2017). Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. European Respiratory Journal, 49(3), 1700214.

  35. Willgoss, T. G., & Yohannes, A. M. (2013). Anxiety disorders in patients with COPD: a systematic review. Respiratory care, 58(5), 858-866. https://doi.org/10.4187/respcare.01862

  36. Wu, T. D., Brigham, E. P., & McCormack, M. C. (2020). Environmental Determinants of Chronic Obstructive Pulmonary Disease. Current opinion in pulmonary medicine, 26(2), 151–156. 

  37. Zhang, Y., Mo, J., Li, Y., Sundell, J., Wargocki, P., Zhang, J., Little, J. C., Corsi, R., Deng, Q., Leung, M. H. K., Fang, L., Chen, W., Li, J., & Sun, Y. (2011). Can commonly-used fan-driven air cleaning technologies improve indoor air quality? A literature review. Atmospheric environment (Oxford, England : 1994), 45(26), 4329–4343.

 

 

Article by

John Keller

Clinical Director | Sports & Musculoskeletal Physiotherapist

John graduated as a Physiotherapist from the Auckland University of Technology with the John Morris memorial prize for outstanding clinical practise in 2003. John has since completed Post Graduate Diplomas in both Sports Medicine and Musculoskeletal Physiotherapy with distinction, also collecting the Searle Shield for excellence in Musculoskeletal Physiotherapy.

 

 

Reviewed by

Dr. Jenny Hynes FACP

Clinical Director | Specialist Musculoskeletal Physiotherapist

Jenny sat extensive examinations to be inducted as a fellow into the Australian College of Physiotherapy in 2009 and gain the title of Specialist Musculoskeletal Physiotherapist, one of only a few physiotherapists in the state to have done so.

 
 
John Keller